research Refining drug benefit. Reducing risk. improving outcomes.

Use of observational methods and automated real-world healthcare data is most impactful if it can complement the evidence gleaned from clinical trials. Thus, pharmacoepidemiologic studies focus on assessments of drug effects in vulnerable populations that may have been under-represented in clinical trials, assessments of rare or long-term effects that require large populations and long follow-up, assessments of treatment effect heterogeneity to enhance our understanding of drug risk-benefit for specific populations, and evaluations of medication use and related policies. Our work spans across various therapeutic areas. At its intersection is the application of rigorous causal inference methods to support the following research foci:
(a) population-based pharmacoepidemiologic studies on drug effectiveness and safety,
(b) development of novel methods especially in the area of measurement,
(c) quality assessment of medication use and related policy and programs, and
(d) development of clinical and regulatory decision-support tools.

Research area

Little people

We evaluate the safety, effectiveness and utilization of medication in children, aiming the fill the evidence gap from clinical trials.

Research area

Regulatory science & program evaluation

We evaluate regulatory programs and policy aimed at enhancing medication use, and support regulatory decision-making with evidence and decision tools.